Mechanism and Signaling

Mechanism of Action

Related Publications

Wang, J., Lan, L., Wu, X., Xu, L., & Miao, Y. 2021. Mechanism of RNA recognition by a Musashi RNA-binding protein. Current research in structural biology, 4, 10–20.

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das Chagas, P. F., Baroni, M., Brassesco, M. S., & Tone, L. G. 2020. Interplay between the RNA binding-protein Musashi and developmental signaling pathways. The journal of gene medicine, 22(1), e3136.

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Cragle, C. E., MacNicol, M. C., Byrum, S. D., Hardy, L. L., Mackintosh, S. G., Richardson, W. A., Gray, N. K., Childs, G. V., Tackett, A. J., & MacNicol, A. M. 2019. Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation. The Journal of biological chemistry, 294(28), 10969–10986.

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Ohyama T, Nagata T, Tsuda K, Kobayashi N, Imai T, Okano H, Yamazaki T, Katahira M. 2012. Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions. Nucleic Acids Res. 40(7):3218–31

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Kawahara H, Okada Y, Imai T, Iwanami A, Mischel PS, Okano H. 2011. Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation. J. Biol. Chem. 286(18):16121–30

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MacNicol MC, Cragle CE, MacNicol A. 2011. Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation. Cell Cycle 10(1):39–44

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Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T. 2010. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature 466(7307):765–68

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de Sousa Abreu R, Sanchez-Diaz PC, Vogel C, Burns SC, Ko D, Burton TL, Vo DT, Chennasamudaram S, Le SY, Shapiro BA, Penalva LO. 2009. Genomic analyses of Musashi1 downstream targets show a strong association with cancer-related processes. J. Biol. Chem. 284(18):12125–35

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Kawahara H, Imai T, Imataka H, Tsujimoto M, Matsumoto K, Okano H. 2008. Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J. Cell Biol. 181(4):639–53

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Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM. 2006. The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1. Mol. Cell. Neurosci. 31(1):85–96

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Sakakibara S, Nakamura Y, Satoh H, Okano H. 2001. RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. J. Neurosci. 21(20):8091–107

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Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H. 2001. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol. Cell. Biol. 21(12):3888–900

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