Journal Articles

Siddall, N. A., Casagranda, F., Johanson, T. M., Dominado, N., Heaney, J., Sutherland, J. M., McLaughlin, E. A., & Hime, G. R. 2022. MiMIC analysis reveals an isoform specific role for Drosophila Musashi in follicle stem cell maintenance and escort cell function. Cell death discovery, 8(1), 455.

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Darai, N., Mahalapbutr, P., Wolschann, P., Lee, V. S., Wolfinger, M. T., & Rungrotmongkol, T. 2022. Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein. Scientific reports, 12(1), 12137.

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Erazo, T., Evans, C. M., Zakheim, D., Chu, K. L., Refermat, A. Y., Asgari, Z., Yang, X., Da Silva Ferreira, M., Mehta, S., Russo, M. V., Knezevic, A., Zhang, X. P., Chen, Z., Fennell, M., Garippa, R., Seshan, V., de Stanchina, E., Barbash, O., Batlevi, C. L., Leslie, C. S., … Kharas, M. G. 2022. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma. Nature communications, 13(1), 5676.

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Sundar, J., Matalkah, F., Jeong, B., Stoilov, P., & Ramamurthy, V. 2021. The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice. The Journal of biological chemistry, 296, 100048.

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Sharma, A., Akagi, K., Pattavina, B., Wilson, K. A., Nelson, C., Watson, M., Maksoud, E., Harata, A., Ortega, M., Brem, R. B., & Kapahi, P. 2020. Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila. Scientific reports, 10(1), 19080.

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Chen, T. C., & Huang, J. R. 2020. Musashi-1: An Example of How Polyalanine Tracts Contribute to Self-Association in the Intrinsically Disordered Regions of RNA-Binding Proteins. International journal of molecular sciences, 21(7), 2289.

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Lan, L., Xing, M., Kashipathy, M., Douglas, J., Gao, P., Battaile, K., Hanzlik, R., Lovell, S., & Xu, L. 2020. Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1. Proteins, 88(4), 573–583.

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Chen, H. Y., Wang, M. L., Laurent, B., Hsu, C. H., Chen, M. T., Lin, L. T., Shen, J., Chang, W. C., Hsu, J., Hung, M. C., Chen, Y. W., Huang, P. I., Yang, Y. P., Li, C. P., Ma, H. I., Chen, C. H., Lin, W. C., & Chiou, S. H. 2020. Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. Theranostics, 10(1), 201–217.

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El-Salhy, M., Hausken, T., & Hatlebakk, J. G. 2020. Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome. Molecular medicine reports, 22(4), 3135–3140.

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Beligala, D. H., De, A., Malik, A., Silver, R., Rimu, K., LeSauter, J., McQuillen, H. J., & Geusz, M. E. 2019. Musashi-2 and related stem cell proteins in the mouse suprachiasmatic nucleus and their potential role in circadian rhythms. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience, 75, 44–58.

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Cragle, C. E., MacNicol, M. C., Byrum, S. D., Hardy, L. L., Mackintosh, S. G., Richardson, W. A., Gray, N. K., Childs, G. V., Tackett, A. J., & MacNicol, A. M. 2019. Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation. The Journal of biological chemistry, 294(28), 10969–10986.

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Belew, M. S., Bhatia, S., Keyvani Chahi, A., Rentas, S., Draper, J. S., & Hope, K. J. 2018. PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells. Stem cell reports, 10(4), 1384–1397.

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MacNicol MC, Cragle CE, McDaniel FK, Hardy LL, Wang Y, Arumugam K, Glazko GV, Wilczynska A, Childs GV, Zhou D, MacNicol AM. 2017. Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2. Sci Rep. 7(1):11503

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Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. 2016. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 534(7607):407-411

Rentas S, Holzapfel N, Belew MS, Pratt G, Voisin V, Wilhelm BT, Bader GD, Yeo GW, Hope KJ. 2016. Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells. Nature 532(7600):508-511

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Hochgreb-Hagele T, Koo DE, Das NM, Bronner ME. 2014. Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants. Stem cells 32, 558–571

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Cragle C, MacNicol AM. 2014. Musashi protein–directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2. J. Biol. Chem. 289(20):14239–51

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Kawase S, Kuwako K, Imai T, Renault-Mihara F, Yaguchi K, Itohara S, Okano H. 2014. Regulatory factor  transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells. Stem Cells Dev. 23(18):2250–61

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Park S-M, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG. 2014. Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs. J. Exp. Med. 211(1):71–87

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Zearfoss NR, Deveau LM, Clingman CC, Schmidt E, Johnson ES, Massi F, Ryder SP. 2014. A conserved three-nucleotide core motif defines Musashi RNA binding specificity. J Biol Chem. 289(51):35530-41

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Ohyama T, Nagata T, Tsuda K, Kobayashi N, Imai T, Okano H, Yamazaki T, Katahira M. 2012. Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions. Nucleic Acids Res. 40(7):3218–31

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Shibata S, Umei M, Kawahara H, Yano M, Makino S, Okano H. 2012. Characterization of the RNA-binding protein Musashi1 in zebrafish. Brain Res. 1462(C):162–73

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Arumugam K, MacNicol MC, Wang Y, Cragle CE, Tackett AJ, Hardy LL, MacNicol AM. 2012. Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes. J. Biol. Chem. 287(13):10639–49

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Wuebben EL, Mallanna SK, Cox JL, Rizzino A. 2012. Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells. PLOS ONE 7(4):e34827

Vo DT, Subramaniam D, Remke M, Burton TL, Uren PJ, Gelfond JA, de Sousa Abreu R, Burns SC, Qiao M, Suresh U, Korshunov A, Dubuc AM, Northcott PA, Smith AD, Pfister SM, Taylor MD, Janga SC, Anant S, Vogel C, Penalva LO. 2012. The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis. Am J Pathol. 181(5):1762-72

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Kawahara H, Okada Y, Imai T, Iwanami A, Mischel PS, Okano H. 2011. Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation. J. Biol. Chem. 286(18):16121–30

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de Andres-Aguayo L, Varas F, Kallin EM, Infante JF, Wurst W, Floss T, Graf T. 2011. Musashi 2 is a  regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice.  Blood 118(3):554–64

Wang XY, Penalva LO, Yuan H, Linnoila RI, Lu J, Okano H, Glazer RI. 2010. Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival. Mol Cancer 9:221

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Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T. 2010. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature 466(7307):765–68

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Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Eber BL, Gilliland DG, Jaenisch R, Daley GQ. 2010. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat. Med. 16(8):903–8

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Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G. 2010. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell 7(1):101–13

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de Sousa Abreu R, Sanchez-Diaz PC, Vogel C, Burns SC, Ko D, Burton TL, Vo DT, Chennasamudaram S, Le SY, Shapiro BA, Penalva LO. 2009. Genomic analyses of Musashi1 downstream targets show a strong association with cancer-related processes. J. Biol. Chem. 284(18):12125–35

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Sureban SM, May R, George RJ, Dieckgraefe BK, McLeod HL, Ramalingam S, Bishnupuri KS, Natarajan G, Anant S, Houchen CW. 2008. Knockdown of RNA binding protein Musashi-1 leads to tumor regression in vivo. Gastroenterology 134(5):1448–58
PubMed

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Kawahara H, Imai T, Imataka H, Tsujimoto M, Matsumoto K, Okano H. 2008. Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J. Cell Biol. 181(4):639–53

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Siddall NA, McLaughlin EA, Marriner NL, Hime GR. 2006. The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity. PNAS 103(22):8402–7

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Charlesworth A, Wilczynska A, Thampi P, Cox LL, MacNicol AM. 2006. Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation. EMBO J. 25(12):2792–801

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Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM. 2006. The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1. Mol. Cell. Neurosci. 31(1):85–96

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Miyanoiri Y, Kobayashi H, Imai T, Watanabe M, Nagata T, Uesugi S, Okano H, Katahira M. 2003. Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, Musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics. J. Biol. Chem. 278(42):41309–15

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Barbouti A, Höglund M, Johansson B, Lassen C, Nilsson PG, Hagemeijer A, Mitelman F, Fioretos T. 2003. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). Cancer Res. 63(6):1202–6

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Potten CS, Booth C, Tudor GL, Booth D, Brady G, Hurley P, Ashton G, Clarke R, Sakakibara S, Okano H. 2003. Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation 71(1):28–41

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Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI. 2003. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A. 100(25):15178-83.

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Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, Ueda S, Uchiyama Y, Noda T, Okano H. 2002. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. PNAS 99(23):15194–99

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Cuadrado A, García-Fernández LF, Imai T, Okano H, Muñoz A. 2002. Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein Musashi-1. Mol. Cell. Neurosci. 20(2):198–210

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Okabe M, Imai T, Kurusu M, Hiromi Y, Okano H. 2001. Translational repression determines a neuronal potential in Drosophila asymmetric cell division. Nature 411(6833):94–98

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Sakakibara S, Nakamura Y, Satoh H, Okano H. 2001. RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. J. Neurosci. 21(20):8091–107

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Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H. 2001. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol. Cell. Biol. 21(12):3888–900

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Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, Ikeuchi T, Tsuji S, Satoh H, Okano H. 1998. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. Genomics 52(3):382–84

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Sakakibara S, Imai T, Hamaguchi K, Okabe M, Aruga J, Nakajima K, Yasutomi D, Nagata T, Kurihara Y, Uesugi S, Miyata T, Ogawa M, Mikoshiba K, Okano H. 1996. Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell. Dev. Biol. 176(2):230–4

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Nakamura M, Okano H, Blendy JA, Montell C. 1994. Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development. Neuron 13(1):67–81

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Reviews

Jiang, L., Xue, S., Xu, J., Fu, X., Wei, J., & Zhang, C. 2022. Prognostic value of Musashi 2 (MSI2) in cancer patients: A systematic review and meta-analysis. Frontiers in oncology, 12, 969632.

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Wang, J., Lan, L., Wu, X., Xu, L., & Miao, Y. 2021. Mechanism of RNA recognition by a Musashi RNA-binding protein. Current research in structural biology, 4, 10–20.

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das Chagas, P. F., Baroni, M., Brassesco, M. S., & Tone, L. G. 2020. Interplay between the RNA binding-protein Musashi and developmental signaling pathways. The journal of gene medicine, 22(1), e3136.

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Kharas MG, Lengner CJ. 2017. Stem Cells, Cancer, and MUSASHI in Blood and Guts. Trends Cancer 3(5):347-356

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Fox RG, Park FD, Koechlein CS, Kritzik M, Reya T. 2015. Musashi signaling in stem cells and cancer. Annu Rev Cell Dev Biol. 31:249-67

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de Andrés-Aguayo L, Varas F, Graf T. 2012. Musashi 2 in hematopoiesis. Curr Opin Hematol. 19(4):268-72

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MacNicol MC, Cragle CE, MacNicol A. 2011. Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation. Cell Cycle 10(1):39–44

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Okano H, Kawahara H, Toriya M, Nakao K, Shibata S, Imai T. 2005. Function of RNA-binding protein Musashi-1 in stem cells. Exp. Cell Res. 306(2):349–56

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Okano H, Imai T, Okabe M. 2002. Musashi: a translational regulator of cell fate. J. Cell. Sci. 115(Pt 7):1355–59

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