Model Organisms
Many different model organisms have been used to study Musashi, most commonly mouse, Drosophila, Xenopus, and zebrafish. Each organism offers different advantages that make it suitable for studying different aspects of this complex gene. Below are some published papers that use each of these model organisms in their Musashi research.
Related Publications
Drosophila
Nakamura M, Okano H, Blendy JA, Montell C. 1994. Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development. Neuron 13(1):67–81 Siddall NA, McLaughlin EA, Marriner NL, Hime GR. 2006. The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity. PNAS 103(22):8402–7 Okabe M, Imai T, Kurusu M, Hiromi Y, Okano H. 2001. Translational repression determines a neuronal potential in Drosophila asymmetric cell division. Nature 411(6833):94–98
Xenopus
MacNicol MC, Cragle CE, MacNicol A. 2011. Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation. Cell Cycle 10(1):39–44 MacNicol MC, Cragle CE, McDaniel FK, Hardy LL, Wang Y, Arumugam K, Glazko GV, Wilczynska A, Childs GV, Zhou D, MacNicol AM. 2017. Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2. Sci Rep. 7(1):11503 Cragle C, MacNicol AM. 2014. Musashi protein–directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2. J. Biol. Chem. 289(20):14239–51 Charlesworth A, Wilczynska A, Thampi P, Cox LL, MacNicol AM. 2006. Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation. EMBO J. 25(12):2792–801 Arumugam K, MacNicol MC, Wang Y, Cragle CE, Tackett AJ, Hardy LL, MacNicol AM. 2012. Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes. J. Biol. Chem. 287(13):10639–49
Zebrafish
Shibata S, Umei M, Kawahara H, Yano M, Makino S, Okano H. 2012. Characterization of the RNA-binding protein Musashi1 in zebrafish. Brain Res. 1462(C):162–73 Hochgreb-Hagele T, Koo DE, Das NM, Bronner ME. 2014. Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants. Stem cells 32, 558–571
